Physiology & Behavior
Although metabolites and energy balance have long been known to play roles in the regulation of food intake, the potential role of fatty
acid metabolism in this process has been considered only recently. Fatty acid synthase (FAS) catalyzes the condensation of acetyl-CoA and
malonyl-CoA to generate long-chain fatty acids in the cytoplasm, while the breakdown of fatty acids (h-oxidation) occurs in mitochondria
and is regulated by carnitine palmitoyltransferase-1 (CPT-1), the rate-limiting step for the entry of fatty acids into the mitochondria....
